Cutaneous Calciphylaxis

摘要: Calciphylaxis (CPX), an uncommon syndrome characterized, in part, by progressive cutaneous vascular calcification, is seen principally the setting of renal failure-associated hyperparathyroidism and difficult to distinguish histologically from other microvasculopathies. We assessed histologic specimens 13 cases clinicopathologically classic CPX skin reviewed documented findings literature. Our series included 7 "early" 6 "late" lesions (absence or presence tissue necrosis, respectively). Histologically, early were subtle almost inapparent microscopically. Late easier recognize because obvious epidermal ulceration, dermal easily mural calcification. The most common finding both groups was acute chronic calcifying septal panniculitis. Endovascular fibroblastic proliferation more advanced lesions. Necrosis collagen identified only a few Frank luminal thrombosis infrequent groups. cited largely mirrored those Although they are relatively nonspecific when considered isolation, histopathologic features allow for diagnosis this potentially lethal disorder combination with one another, particularly if detailed clinical data also available.