Software sensors for fermentation processes.
作者： Heléne Sundström , Sven-Olof Enfors
DOI: 10.1007/S00449-007-0157-5
关键词: Industrial and production engineering 、 Engineering 、 Growth rate 、 Bioreactor 、 Fermentation 、 Software 、 Biomass 、 Environmental engineering 、 Process engineering 、 State variable 、 Oxygen
摘要: Four software sensors based on standard on-line data from fermentation processes and simple mathematical models were used to monitor a number of state variables in Escherichia coli fed-batch processes: the biomass concentration, specific growth rate, oxygen transfer capacity bioreactor, new RO/S sensor which is ratio between energy substrate consumption. The variable grows continuously culture with constant glucose feed, reflects increasing maintenance demand at declining rate. also responded rapid pH shift-downs reflecting for energy. It suggested that this may be extent physiological stress demands survival.
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Tsuneo Yamanè, Shoichi Shimizu, Fed-batch techniques in microbial processes Bioprocess Parameter Control. ,vol. 30, pp. 147- 194 ,(1984) , 10.1007/BFB0006382
Ling Han, Physiology of Escherichia coli in batch and fed-batch cultures with special emphasis on amino acid and glucose metabolism Bioteknologi. ,(2002)
Stephan Kueppers, Markus Haider, Process analytical chemistry - future trends in industry Analytical and Bioanalytical Chemistry. ,vol. 376, pp. 313- 315 ,(2003) , 10.1007/S00216-003-1907-0
J. J. L. Iversen, J. K. Thomsen, R. P. Cox, On-line growth measurements in bioreactors by titrating metabolic proton exchange Applied Microbiology and Biotechnology. ,vol. 42, pp. 256- 262 ,(1994) , 10.1007/BF00902726
Joachim Huth, Rosel Blasig, Sabine Werner, Hans-Georg Müller, The proton extrusion of growing yeast cultures as an on-line parameter in fermentation processes: Determination of biomass production and substrate consumption in batch experiments with Candida maltosa EH 15 D Journal of Basic Microbiology. ,vol. 30, pp. 481- 488 ,(1990) , 10.1002/JOBM.3620300705
MichaelJ. Kosinski, Ursula Rinas, JamesE. Bailey, Isopropyl-β- d -thiogalactopyranoside influences the metabolism of Escherichia coli Applied Microbiology and Biotechnology. ,vol. 36, pp. 782- 784 ,(1992) , 10.1007/BF00172194
Heléne Sundström, Fredrik Wållberg, Erika Ledung, Bo Norrman, Christopher J. Hewitt, Sven-Olof Enfors, Segregation to non-dividing cells in recombinant Escherichia coli fed-batch fermentation processes. Biotechnology Letters. ,vol. 26, pp. 1533- 1539 ,(2004) , 10.1023/B:BILE.0000044458.29147.75
Anna Marya Jobé, Christoph Herwig, Martin Surzyn, Bernhard Walker, Ian Marison, Urs von Stockar, Generally applicable fed-batch culture concept based on the detection of metabolic state by on-line balancing. Biotechnology and Bioengineering. ,vol. 82, pp. 627- 639 ,(2003) , 10.1002/BIT.10610
João A. Lopes, Paula F. Costa, Teresa P. Alves, José C. Menezes, Chemometrics in bioprocess engineering: process analytical technology (PAT) applications Chemometrics and Intelligent Laboratory Systems. ,vol. 74, pp. 269- 275 ,(2004) , 10.1016/J.CHEMOLAB.2004.07.006
Frank Hoffmann, Michael Schmidt, Ursula Rinas, Simple technique for simultaneous on-line estimation of biomass and acetate from base consumption and conductivity measurements in high-cell density cultures of Escherichia coli. Biotechnology and Bioengineering. ,vol. 70, pp. 358- 361 ,(2000) , 10.1002/1097-0290(20001105)70:3<358::AID-BIT14>3.0.CO;2-T