The role of hypoxia-inducible factors in organ donation and transplantation: the current perspective and future opportunities.
作者： M. Z. Akhtar , A. I. Sutherland , H. Huang , R. J. Ploeg , C. W. Pugh
DOI: 10.1111/AJT.12737
关键词: Ischemia 、 Bioinformatics 、 Transplantation 、 Organ donation 、 Organ transplantation 、 Kidney transplantation 、 Medicine 、 Lung transplantation 、 Liver transplantation 、 Immunology 、 Reperfusion injury
摘要: Hypoxia-inducible factors are the universal cellular oxygen-sensitive transcription that activate a number of hypoxia responsive genes, some which responsible for protective functions. During organ donation, allografts exposed to significant periods and ischemia. Exploiting this pathway during donor management preservation could prevent reduce allograft injury improve outcomes transplantation. We review evidence on in preservation, drawing experimental studies ischemia reperfusion focusing kidney, liver, cardiac lung major technical challenges exploring suggest potential future avenues research.
core.ac.uk 
sci-hub.se 参考文章(45)
M. A. I. Keränen, R. Tuuminen, S. Syrjälä, R. Krebs, G. Walkinshaw, L. A. Flippin, M. Arend, P. K. Koskinen, A. I. Nykänen, K. B. Lemström, Differential Effects of Pharmacological HIF Preconditioning of Donors Versus Recipients in Rat Cardiac Allografts American Journal of Transplantation. ,vol. 13, pp. 600- 610 ,(2013) , 10.1111/AJT.12064
C. W. Pugh, C. C. Tan, R. W. Jones, P. J. Ratcliffe, Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 10553- 10557 ,(1991) , 10.1073/PNAS.88.23.10553
A. Amador, L. Grande, J. Martí, R. Deulofeu, R. Miquel, A. Solá, G. Rodriguez-Laiz, J. Ferrer, C. Fondevila, R. Charco, J. Fuster, G. Hotter, J. C. García-Valdecasas, Ischemic pre-conditioning in deceased donor liver transplantation: A prospective randomized clinical trial American Journal of Transplantation. ,vol. 7, pp. 2180- 2189 ,(2007) , 10.1111/J.1600-6143.2007.01914.X
David Lando, Daniel J Peet, Dean A Whelan, Jeffrey J Gorman, Murray L Whitelaw, Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science. ,vol. 295, pp. 858- 861 ,(2002) , 10.1126/SCIENCE.1068592
M.Z. Akhtar, T. Henderson, A. Sutherland, T. Vogel, P.J. Friend, Novel Approaches to Preventing Ischemia-Reperfusion Injury During Liver Transplantation Transplantation Proceedings. ,vol. 45, pp. 2083- 2092 ,(2013) , 10.1016/J.TRANSPROCEED.2013.04.004
Melanie L. Hart, Martina Henn, David Köhler, Doris Kloor, Michel Mittelbronn, Iris C. Gorzolla, Gregory L. Stahl, Holger K. Eltzschig, Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury The FASEB Journal. ,vol. 22, pp. 2784- 2797 ,(2008) , 10.1096/FJ.07-103911
Patrick Paulus, Pia Ockelmann, Sabine Tacke, Nora Karnowski, Peter Ellinghaus, Bertram Scheller, Johannes Holfeld, Anja Urbschat, Kai Zacharowski, Deguelin Attenuates Reperfusion Injury and Improves Outcome after Orthotopic Lung Transplantation in the Rat PLoS ONE. ,vol. 7, pp. e39265- ,(2012) , 10.1371/JOURNAL.PONE.0039265
E. T. Clambey, E. N. McNamee, J. A. Westrich, L. E. Glover, E. L. Campbell, P. Jedlicka, E. F. de Zoeten, J. C. Cambier, K. R. Stenmark, S. P. Colgan, H. K. Eltzschig, Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 16418- 16419 ,(2012) , 10.1073/PNAS.1202366109
Judit Kiss, Johanna Kirchberg, Martin Schneider, Molecular oxygen sensing: implications for visceral surgery Langenbeck's Archives of Surgery. ,vol. 397, pp. 603- 610 ,(2012) , 10.1007/S00423-012-0930-Z
Martin Albrecht, Karina Zitta, Berthold Bein, Gunther Wennemuth, Ole Broch, Jochen Renner, Torben Schuett, Fabian Lauer, Daniela Maahs, Lars Hummitzsch, Jochen Cremer, Kai Zacharowski, Patrick Meybohm, Remote ischemic preconditioning regulates HIF-1α levels, apoptosis and inflammation in heart tissue of cardiosurgical patients: a pilot experimental study Basic Research in Cardiology. ,vol. 108, pp. 314- 314 ,(2013) , 10.1007/S00395-012-0314-0