Analytical techniques for the characterization of Antibody Drug Conjugates : Challenges and prospects
作者： Rabin Neupane , Jonas Bergquist
关键词: Drug 、 Nanotechnology 、 Antibody-drug conjugate 、 Characterization (materials science) 、 Computer science
摘要: Antibody drug conjugates are increasingly being researched for the treatment of cancer. Accurate and reliable characterization ADCs is inevitable their development as potential therapeutic agent. Different analytical techniques have been used in order to decipher heterogeneous nature antibody conjugates, enabling successful characterization. This review will summarize specially three major tools i.e. UV–Vis spectroscopy, liquid chromatography, mass spectrometry conjugates. In this review, challenges during analysis due inherent features summarized along with modifications intended address each challenge.
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