Enhanced Antioxidant Activity under Biomimetic Settings of Ascorbic Acid Included in Halloysite Nanotubes
作者： Andrea Baschieri , Riccardo Amorati , Tiziana Benelli , Laura Mazzocchetti , Emanuele D’Angelo
关键词: Antioxidant 、 Acetonitrile 、 Reaction rate constant 、 Aqueous solution 、 Chemistry 、 DPPH 、 Autoxidation 、 Halloysite 、 Ascorbic acid 、 Nuclear chemistry
摘要: Antioxidant activity of native vitamin C (ascorbic acid, AH2) is hampered by instability in solution. Selective loading AH2 into the inner lumen natural halloysite nanotubes (HNT) yields a composite nanoantioxidant (HNT/AH2), which was characterized and investigated for its reactivity with persistent 1,1-diphenyl-2-picrylhydrazyl (DPPH•) radical transient peroxyl radicals inhibited autoxidation organic substrates, both solution (acetonitrile) buffered (pH 7.4) water comparison AH2. HNT/AH2 showed excellent antioxidant performance being more effective than ascorbic acid 131% acetonitrile 290% (three-fold) aqueous solution, under identical settings. Reaction has rate constant 1.4 × 106 M−1 s−1 5.1 104 s−1, respectively, acetonitrile, at 30 °C. Results offer physical understanding factors governing reactivity. Improved unprecedented among forms stabilized relevance discussed on kinetic grounds.
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sci-hub.st 参考文章(52)
Efficient Transdermal Penetration and Improved Stability of L-Ascorbic Acid Encapsulated in an Inorganic Nanocapsule Bulletin of The Korean Chemical Society. ,vol. 24, pp. 499- 503 ,(2003) , 10.5012/BKCS.2003.24.4.499
Shaun A. Mason, Raquel Baptista, Paul A. Della Gatta, Adel Yousif, Aaron P. Russell, Glenn D. Wadley, High-dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males. Free Radical Biology and Medicine. ,vol. 77, pp. 130- 138 ,(2014) , 10.1016/J.FREERADBIOMED.2014.09.013
Polona Špiclin, Miha Homar, Andreja Zupančič-Valant, Mirjana Gašperlin, Sodium ascorbyl phosphate in topical microemulsions. International Journal of Pharmaceutics. ,vol. 256, pp. 65- 73 ,(2003) , 10.1016/S0378-5173(03)00063-2
Marco Lucarini, Gian Franco Pedulli, Luca Valgimigli, Riccardo Amorati, Francesco Minisci, Thermochemical and kinetic studies of a bisphenol antioxidant. Journal of Organic Chemistry. ,vol. 66, pp. 5456- 5462 ,(2001) , 10.1021/JO015653S
M. Gallarate, M.E. Carlotti, M. Trotta, S. Bovo, On the stability of ascorbic acid in emulsified systems for topical and cosmetic use. International Journal of Pharmaceutics. ,vol. 188, pp. 233- 241 ,(1999) , 10.1016/S0378-5173(99)00228-8
Aurelia Magdalena Pisoschi, Aneta Pop, The role of antioxidants in the chemistry of oxidative stress: A review. European Journal of Medicinal Chemistry. ,vol. 97, pp. 55- 74 ,(2015) , 10.1016/J.EJMECH.2015.04.040
E. Kimoto, H. Tanaka, T. Ohmoto, M. Choami, Analysis of the Transformation Products of Dehydro-L-Ascorbic Acid by Ion-Pairing High-Performance Liquid Chromatography Analytical Biochemistry. ,vol. 214, pp. 38- 44 ,(1993) , 10.1006/ABIO.1993.1453
Yuri M. Lvov, Dmitry G. Shchukin, Helmuth Möhwald, Ronald R. Price, Halloysite Clay Nanotubes for Controlled Release of Protective Agents ACS Nano. ,vol. 2, pp. 814- 820 ,(2008) , 10.1021/NN800259Q
Lanny Sapei, Lie Hwa, Study on the Kinetics of Vitamin C Degradation in Fresh Strawberry Juices Procedia Chemistry. ,vol. 9, pp. 62- 68 ,(2014) , 10.1016/J.PROCHE.2014.05.008
Caterina Viglianisi, Veronica Di Pilla, Stefano Menichetti, Vincent M. Rotello, Gabriele Candiani, Chiara Malloggi, Riccardo Amorati, Linking an α-Tocopherol Derivative to Cobalt(0) Nanomagnets: Magnetically Responsive Antioxidants with Superior Radical Trapping Activity and Reduced Cytotoxicity Chemistry: A European Journal. ,vol. 20, pp. 6857- 6860 ,(2014) , 10.1002/CHEM.201402289