Subcutaneously administered ANTI-IL-6 receptor antibody
作者： Angelika M. Jahreis , Johannes F. Schmidt , Min Bao , Kimio Terao , Xiaoping Zhang
DOI:
关键词: Tocilizumab 、 Rheumatoid arthritis 、 Receptor antibody 、 Anti-IL-6 、 Giant cell arteritis 、 Pharmacology 、 Receptor 、 Antibody 、 Medicine 、 Immunology 、 Arthritis
摘要: The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic (JIA), systemic JIA (sJIA), polyarticular course (pcJIA), sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective subcutaneous administration in patients disorders. addition, formulations devices useful are disclosed.
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