Cross-Reactive Antigens: Their Potential for Immunization-Induced Immunity to Gram-Negative Bacteria

摘要: The involvement of multiple species and serologic types in gram-negative bacteremia prompted evaluation immunization with shared, cross-reactive antigens gram negative bacilli. Active passive Re chemotype mutants Salmonella minnesota afforded significant protection against heterologous bacilli were considerably more effective than smooth S. or its Ra, Rb, Rc, Rd1 Rd2 mutants. Since the lipopolysaccharide mutant is composed solely 2-keto-3-deoxycotonate (KDO) lipid A, protective activity antibody to A was evaluated. Immunization protected granulocytopenic rabbits lethal mice challenge endotoxins, whereas had no activity. In concomitant clinical studies, high titers at onset associated a diminution frequency shock death, which independent any effect O-specific antibody.