High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction
作者： Angeliki Chalkiadaki , Leonard Guarente
DOI: 10.1016/J.CMET.2012.07.003
关键词: Adipose tissue 、 Endocrinology 、 3T3 cells 、 Inflammation 、 Sirtuin 1 、 Adipose tissue macrophages 、 Regulation of gene expression 、 Gene expression 、 Caspase 1 、 Internal medicine 、 Biology
摘要: … mice, suggesting that dietary stress signals inhibit the activity of SIRT1. Indeed, we show that high-fat diet induces the cleavage of SIRT1 protein in adipose tissue by the inflammation-…
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