Hedgehog Signaling Modulates Glial Proteostasis and Lifespan

摘要: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown. Here, we investigated whether the is active adult life Drosophila melanogaster, and uncovered a protective for coordinating correct proteostasis glial cells. Adult-specific depletion of reduces lifespan, locomotor activity, dopaminergic neuron integrity. Conversely, increased expression extends lifespan improves fitness. Moreover, activation glia rescues age-associated defects hedgehog mutants. regulates downstream chaperones, whose overexpression cells was sufficient to rescue shortened Finally, demonstrate ability Alzheimer's disease model expressing human amyloid beta glia. Overall, propose that requisite determination