Detailing sexual outcomes after treatment of localised prostate cancer with focal therapy using various energy sources: protocol for a mixed-methods study

摘要: Introduction Focal therapy has emerged as a promising treatment option for men with localised prostate cancer. However, most of the evaluation postoperative function taken place at relatively high, non-granular level. Most data we use to provide informed consent our patients is obtained from retrospective series, or derived prospective studies whose primary outcome was oncological. Finally, have focused on erectile and overlooked other, presumably important, elements male sexual function. The present study aims studying in-depth consequences focal various energy sources. Methods analysis This will be mixed-methods research based cohort, recruited in parallel. cohort consist treated irreversible electroporation, three energies. Participants two UK urology centres, one National Health Service private. On consent, fill self-administered validated questionnaires (International Index Erectile Function-15 (IIEF-15), Male Sexual Questionnaire-Ejaculatory Dysfunction-Short Form (MSHQ-EjD-SF)) semistructured interviews organised collect patients’ expectations changes domains such erection, ejaculation, orgasm, libido/sexual desire, masculinity/virility, penile morphology, pain discomfort, regret, shame, cancer-related stress, overall impact partner satisfaction. An exploratory thematic performed detail recurring themes that grouped into clusters experiences. We then able find agreement disagreement illustrated using exemplar patient quotations. Ethics dissemination Ethical approval (Regional Committee reference 20/NW/0335), well Research Authority approval. Results published open-access peer-reviewed journals. Findings also translated information resources (leaflets, online sheets). Trial registration number ISRCTN11634296; Pre-results.