Gene Therapy for Spinal Cord Injury

摘要: This chapter reviews the steady advances that have been made in neuroregeneration research with development of advanced gene and cell therapy to promote regeneration animal models for spinal cord injury (SCI). It also includes a brief description pathophysiology SCI predominantly used models. Spinal repair strategies comprise multi-factorial approach addressing several issues, including optimization survival function spared central nervous system neurons modulation trophic inhibitory influences guide axonal regrowth. Viral vector-mediated transfer neurotrophic factor genes by direct vector injections is emerging as novel effective strategy express proteins injured system, cord. Ex vivo additionally explored way more efficiently bridge lesion cavities cellular implants regeneration. Several viral systems, based on herpes simplex virus, adenovirus, adeno-associated lentivirus moloney leukemia virus employed. The genetic modification fibroblasts, Schwann cells, olfactory ensheathing glia cells stem prior implantation has resulted improved nerve guides. developed combination growth-promoting molecules either delivered via genetically modified or discussed this review neutralization outgrowth factors present myelin neural scar.