Pathological and molecular analysis of a composite lymphoma of mantle cell lymphoma and Epstein-Barr virus-positive follicular lymphoma.
作者： Yuri Miyazawa , Akihiko Yokohama , Takuma Ishizaki , Norifumi Tsukamoto , Hiromi Koshi
DOI: 10.1007/S12185-020-03035-0
关键词: Biology 、 Virus 、 Lymph node 、 Follicular lymphoma 、 Epstein–Barr virus 、 Internal medicine 、 Pathology 、 Epstein-Barr Virus Positive 、 Mantle cell lymphoma 、 Hematology 、 Lymphoma
摘要: Composite lymphoma (CL) is a very rare clinical entity defined by the presence of two or more different subtypes in same lymph node. We report case CL 78-year-old male presenting with leukocytosis and swelling multiple nodes. A left axillary node biopsy showed atypical lymphocytes both interfollicular follicular areas. Immunohistochemistry revealed that mantle cell (MCL) was mainly present area (FL) area. Polymerase chain reaction analysis immunoglobulin heavy gene rearrangements confirmed they were clonally related neoplasms. However, Epstein-Barr virus (EBV) DNA detected only FL cells, suggesting MCL had split into clones early steps pathogenesis. This first reported EBV-negative B-cell non-Hodgkin (NHL) EBV-positive NHL clonal relationship. discuss developmental processes these lymphomas.
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