Serotonin Binding Protein: Role in Transmitter Storage in Central and Peripheral Serotonergic Neurons

摘要: Serotonin binding protein was first found in the brain 1974 (Tamir and Huang, 1974). The regional distribution of SBP Kuhar, 1975) spinal cord Gershon, 1979) shown to parallel that serotonin (5-HT). Since, addition, amount forebrain is decreased by lesioning nuceli median raphe it seems likely an intrinsic component serotonergic neurons 1975). This conclusion supported observation accumulates above, decreases below, lesions 1979). Although has only partially been purified, unusually high affinity for 5-HT, inhibition 5-HT bindin reserpine, characteristic dependence on Fe+2 enable be recognized et al., 1976). 5-HT-Fe+2-SBP complex a mobility 10% SDS-polyacrylamide gels corresponding 60,000 daltons (figure 1).