Effect of change in activity level of catecholaminergic systems on motor, respiratory, and cardiac activities in fetal rats

摘要: Parameters of motor, respiratory, and cardiac activities were studied in rat embryos (E17–20) after changes activity level catecholaminergic systems. To conditions for excessive catecholamines, the animals administered individually with L-DOPA at doses 25, 50, 100 mg/kg. Also was action blockade D1-(antagonist—CHS-23390, 0.1 mg/kg), D2-(antagonist—sulpiride, 50 mg/kg) dopaminic, β2-(antagonist—propranolol, 1 adrenergic receptors. It found E17–18 that DOPA administration regardless dose, while E19–20 dose-dependently produces continuous generalized activity. Between E18 E19, ontogenetically novel is appearance 92% stereotypical head movements (circular movements, lateral dorsoventral flexions) following near-second rhythm. Injection to increased 2–6 times number respiratory gasping time E17–20 decreased amount episodes rhythmical respiration E19–20. No significant heart rate observed introduction E17–20. There noted a tendency weak acceleration rate. The motor systems due rise catecholamine are not connected activation dopamine system, as they reduced by