Pseudotrienic acids A and B, two bioactive metabolites from Pseudomonas sp. MF381-IODS.

摘要: Bioassay-guided fractionation of the liquid culture broth Pseudomonas sp. MF381-IODS yielded two new antimicrobial substances, identified as (2E,4E,6E)-9-[((2S,3R)-3-hydroxy-4-{[(3E,5E,7RS)-7-hydroxy-4-methylhexadeca-3,5-dienoyl]amino}-2-methylbutanoyl)amino]nona-2,4,6-trienoic acid and tetradeca equivalent, named pseudotrienic acids A (1) B (2), respectively. The compounds are prone to lactone formation, their structures suggest them be derived from ring opening a macrolide. Pseudotrienic inhibited growth Staphylococcus aureus (MIC 70 μg/mL) syringae pv. μg/mL). Two known compounds, polyketide 2,3-deepoxy-2,3-didehydrorhizoxin (3) tryptophan-derived pyrrolnitrin (4), were also identified.