IgG antigens of the C gamma 2 and C gamma 3 homology regions interacting with rheumatoid factors.
作者： M. W. Turner , J. B. Natvig , P. I. Gaarder
DOI:
关键词: Antigen 、 Igg subclasses 、 Immunology 、 Molecular biology 、 Fc fragment 、 Chemistry 、 Homology (biology) 、 Haemagglutination inhibition
摘要: Haemagglutination inhibition experiments were used to study the interaction of several well-defined rheumatoid factors with pFc' fragments (≡Cγ3 homology regions) prepared from all four IgG subclasses. The results suggest that interact antigens located in both regions Fc fragment. A minimum reactive is suggested—one Cγ3 region and three more Cγ2 region. This multiplicity may contribute formation factor-IgG complexes therefore play a role complement-fixing activity such complexes.
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