Physical-mechanical properties of film-coated soft gelatin capsules
作者： L Felton
DOI: 10.1016/0378-5173(95)04212-1
关键词: Adhesion 、 Plasticizer 、 Triethyl citrate 、 Coating 、 Ultimate tensile strength 、 Film coating 、 Polymer 、 Composite material 、 Polymer chemistry 、 Gelatin 、 Materials science
摘要: Abstract Soft gelatin capsules containing ibuprofen dissolved in either PEG 400 or Miglyol® 812 were coated with an aqueous dispersion of Eudragit® L 30 D-55 using a Mini Hi-Coater. The physical-mechanical properties the capsules, including tensile strength, Young's modulus and toughness, determined Chatillon DFGS50 force gauge attached to TCD-200 motorized test stand. diametral compression tests conducted at rate 12.7 mm/minute. Force-deflection curves obtained mathematically manipulated yield stress-strain diagrams. influence two plasticizing agents, triethyl citrate (TEC) tributyl (TBC), on was determined. hydrophilic plasticizer TEC found be best for acrylic films, regardless fill liquid. uncoated soft function Temperature humidity capsules. adhesion between capsule polymer dependent both liquid coating formulation. Coating dispersions plasticized exhibited good 812, whereas TBC film showed coatings PEG-containing increased substrate over time when stored high temperature humidity.
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