Synthesis of 2,5-disubstituted oxazoles via cobalt(III)-catalyzed cross-coupling of N-pivaloyloxyamides and alkynes
作者： Xiaolong Yu , Kehao Chen , Qi Wang , Wenjing Zhang , Jin Zhu
DOI: 10.1039/C7CC08611C
关键词: Coupling (electronics) 、 Internal oxidation 、 Combinatorial chemistry 、 Chemistry 、 Cycloaddition 、 Catalysis 、 Substrate (chemistry) 、 Cobalt
摘要: An efficient synthesis of 2,5-disubstituted oxazoles via Co(III) catalysis is described herein. The achieved under mild conditions through [3+2] cycloaddition N-pivaloyloxyamides and alkynes. reaction operates an internal oxidation pathway features a very broad substrate scope. one-step natural products such as texamine balsoxin has been demonstrated this protocol.
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