N-Glucuronidation of Drugs and Other Xenobiotics

作者: Sanna Kaivosaari

DOI:

关键词: MetaboliteGlucuronidationBiological activityUGT1A4ChemistryXenobioticBiochemistryEnzymeGlucuronideMicrosome

摘要: … As an example, the ability to form quaternary ammonium glucuronides from … N-glucuronidation. The goal of this study was to characterize species differences related to Nglucuronidation …

参考文章(151)
Edward L. LeCluyse, Eliane Alexandre, Geraldine A. Hamilton, Catherine Viollon-Abadie, D. James Coon, Summer Jolley, Lysiane Richert, Isolation and culture of primary human hepatocytes. Methods of Molecular Biology. ,vol. 290, pp. 207- 229 ,(2005) , 10.1385/1-59259-838-2:207
Simon A Roberts, Drug metabolism and pharmacokinetics in drug discovery. Current Opinion in Drug Discovery & Development. ,vol. 6, pp. 66- 80 ,(2003)
Brian Davies, Tim Morris, Physiological Parameters in Laboratory Animals and Humans Pharmaceutical Research. ,vol. 10, pp. 1093- 1095 ,(1993) , 10.1023/A:1018943613122
Su-Er W. Huskey, Shuet-Hing Lee Chiu, Species differences in N-glucuronidation. Drug Metabolism and Disposition. ,vol. 26, pp. 838- 847 ,(1998)
Brian Burchell, David J. Lockley, Adam Staines, Yoshihiro Uesawa, Michael W.H. Coughtrie, Substrate specificity of human hepatic udp-glucuronosyltransferases. Methods in Enzymology. ,vol. 400, pp. 46- 57 ,(2005) , 10.1016/S0076-6879(05)00003-0
Pia Lautala, Maija Kivimaa, Hannele Salomies, Eivor Elovaara, Jyrki Taskinen, Glucuronidation of entacapone, nitecapone, tolcapone, and some other nitrocatechols by rat liver microsomes. Pharmaceutical Research. ,vol. 14, pp. 1444- 1448 ,(1997) , 10.1023/A:1012133008134
Anna Radominska‐Pandya, Mohamed Ouzzine, Sylvie Fournel‐Gigleux, Jacques Magdalou, Structure of UDP-glucuronosyltransferases in membranes. Methods in Enzymology. ,vol. 400, pp. 116- 147 ,(2005) , 10.1016/S0076-6879(05)00008-X
W P Bishop, T R Tephly, M D Green, Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides. Drug Metabolism and Disposition. ,vol. 23, pp. 299- 302 ,(1995)
P. Gripon, S. Rumin, S. Urban, J. Le Seyec, D. Glaise, I. Cannie, C. Guyomard, J. Lucas, C. Trepo, C. Guguen-Guillouzo, Infection of a human hepatoma cell line by hepatitis B virus Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 15655- 15660 ,(2002) , 10.1073/PNAS.232137699