Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease
作者： Xiaojing Jiao , Dong Zhang , Quan Hong , Lei Yan , Qiuxia Han
DOI: 10.1007/S11684-019-0715-7
关键词: Netrin 、 Endogeny 、 Downregulation and upregulation 、 Angiogenesis 、 Cancer research 、 Proto-oncogene tyrosine-protein kinase Src 、 Cell migration 、 Medicine 、 Axon guidance 、 Receptor 、 General Medicine
摘要: Netrin-1, an axon guidance factor, and its receptor UNC5B play important roles in axonal development angiogenesis. This study examined netrin-1 expression kidneys with diabetic kidney disease (DKD) investigated their Netrin-1 were upregulated streptozotocininduced DKD Wistar rats, was compared that healthy controls. However, exogenous UNC5B-depleted human renal glomerular endothelial cells (HRGECs) inhibited cell migration tubulogenesis. effect likely associated SRC pathway deactivation. treatment also eliminated the pro-angiogenic effects of VEGF-165 on UNC5B-silenced HRGECs. These results indicate antagonizes upregulation contributes partly to enhancing angiogenesis DKD. Therefore, introducing depleting endogenous are potential strategies for reducing incidence early mitigating injury
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