Tissue specific promoters and transgenic animals for the screening of pharmaceuticals
作者： James F. Crish , Richard L. Eckert
DOI:
关键词: Cancer research 、 Spleen 、 Carcinogen 、 Lymph 、 Epidermis (botany) 、 Cancer 、 Involucrin 、 Rectum 、 Biology 、 Transgene 、 Pathology
摘要: The present invention provides human involucrin (hINV) sequences having tissue specific and cell type promoter activity. provided herein direct expression to suprabasal cells of stratifying epithelia. further methods for the production transgenic animals which contain a hINV sequence directs papillomavirus 16 oncogenes (or other oncogenes). These display cervical epidermal hyperplasias as well cancer trachea, esophagus, colon, epidermis, anus/rectum, lymph nodes, spleen lung. provide useful model screening potential anti-neoplastic compounds, carcinogens, co-carcinogens number cancers.
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