Opiate antagonists and agonists and feeding in sheep

摘要: Abstract Recent evidence indicates that endogenous opiate peptides may be involved in the control of food intake. In previous experiments, injection β-endorphin has stimulated intake and peripheral injections antagonist, naloxone, decreased rats. present water intakes sheep were measured response to peripherally administered antagonists continuous lateral ventricular administration agonists. Intravenous both naloxone (0.03, 0.062 0.125 mg/kg) 3–4(hydroxyl-phenyl)-3-4-dimethyl-piperidine propiophenone maleate for up 90 min 4-hr fasted sheep. water-deprived sheep, did not affect or body temperature first 4 hr but depressed 24 Continuous 90-min 26, 51 102 nmoles/min agonist D-ala 2 -met-enkephalinamide (DME) increased satiated mg/kg blocked increase elicited by intraventricular DME. contrast, kyotorphin, a releasor enkephalin brain, Thus, intracerebroventricular agonists intake; feeding induced