Associations between levels of insulin-like growth factor 1 and sinusoidal obstruction syndrome after allogeneic haematopoietic stem cell transplantation.

摘要: Allogeneic myeloablative haematopoietic stem cell transplantation (HSCT) is challenged by severe adverse events, as cytotoxic effects of the conditioning may result in systemic inflammation, leaky epithelial barriers and organ toxicities, contributing to treatment-related morbidity mortality. We hypothesised that insulin-like growth factor-1 (IGF-1), a mediator proliferation various tissues, attenuate chemotherapy-induced tissue damage after HSCT. prospectively measured plasma levels IGF-1 its binding protein 3 (IGFBP-3) 41 patients undergoing IGFBP-3 were inversely correlated with C-reactive interleukin-6 post In multivariate analyses, low before associated increased risk developing sinusoidal obstruction syndrome (SOS; OR=5.00 per 1 SDS decrease (95% CI: 1.45–16.67), P=0.011 (1.37–20.00), P=0.015, respectively). Furthermore, pre-transplant fluid retention during first 21 days transplant (OR=7.69 1.59–33.33), P=0.012, OR=2.94 (1.03–8.33), P=0.045). These data suggest high have protective effect against SOS, possibly attenuating prove useful predictive biomarkers SOS.