An in vitro comparison of the effects of voluven (6% hydroxyethyl starch 130/0.4) and hespan (6% hydroxyethyl starch 670/0.75) on measures of blood coagulation in canine blood

摘要: Objective To assess primary and secondary hemostasis following in vitro dilution of canine whole blood (WB) with hydroxyethyl starch (HES) 130/0.4 HES 670/0.75. Design In experimental study. Setting Private practice, teaching hospital. Animals Twenty-five healthy dogs. Interventions Each dog underwent venipuncture 18 mL venous was sampled once. Measurements Main Results Collected separated 4 aliquots. Aliquot A served as baseline sample. The remaining tubes WB were diluted 0.9% saline, 670/0.75 at a ratio 1:5.5. Dilutional effects evaluated using prothrombin time (PT), activated partial thromboplastin (aPTT), packed cell volume (PCV), thromboelastography (TEG), platelet closure (Ct), which measured function analyzer (PFA). Clot strength (ie, G value) calculated from TEG values. Significant increases PT (P < 0.05) aPTT documented saline. Dilution resulted significant hypocoagulable changes K, MA compared to When comparing saline 670/0.75, both R K values significantly increased 0.05). value when 670/0.75. Ct prolonged after solutions but not saline. Conclusions Dilution hemostasis. Although there small differences between no evident this study. This may suggest would be minimal bleeding risk either solution is administered dogs low doses. Clinical relevance our findings requires further investigation.