Proteodynamics and aging of eukaryotic cells.
作者： Jacek M. Witkowski , Ewa Bryl , Tamas Fulop
DOI: 10.1016/J.MAD.2021.111430
关键词: Neuroscience 、 Translation (biology) 、 Proteostasis 、 Computer science 、 Proteome
摘要: Abstract All aspects of each protein existence in the eukaryotic cells, starting from pre-translation events, through translation, multiple different post-translational modifications, functional life and eventual proteostatic removal after loss functionality changes physico-chemical properties, can be collectively called proteodynamics. With aging, passing time as well accumulating effects exposures, interactions wearing-off lead to problems at above mentioned stages, eventually leading general malfunction proteome. This work briefly reviews summarizes current knowledge concerning this important topic.
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