Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer.

摘要: Expression of cyclooxygenase-2 (COX-2) and matrix metalloproteinase-2 (MMP-2) associates with reduced survival in human breast cancer. COX-2 may be directly involved mammary carcinogenesis, since expression is sufficient for formation tumors transgenic mice, selective inhibitors can suppress tumorigenesis rodent models MMP-2 an extracellular degrading proteolytic enzyme that bas been linked to invasion metastasis. A direct link between exist, inhibition activity result reduction activity. In this study we analyzed protein tissue array specimens 278 invasive cancers by immunohistochemistry. Immunopositivity these two markers was correlated each other various clinicopathological parameters including survival. We found high 30% 83% the cancer specimens, there a positive association factors (p=0.003). It especially evident whenever high, almost invariably (95%). Furthermore, either or associated decreased disease specific when compared MPP-2 low group (p=0.026 p=0.021, respectively). Taken together, our results indicate both are poor prognosis