Method of diagnosing amyotrophic lateral sclerosis

作者: Michael Strong

DOI:

关键词: AntibodyAntigenImmunologyAmyotrophic lateral sclerosisChemistryPhosphorylationPathology

摘要: A method of diagnosing ALS in a mammal is provided comprising the step analyzing tau-containing sample obtained from to determine whether includes pT175 tau, wherein phosphorylation at position 175 tau indicative ALS. Antigenic polypeptides may be used method, as well antibodies prepared using antigenic polypeptides.

参考文章(6)
Hugo Vanderstichele, Eugeen Vanmechelen, Diagnosis of tauopathies ,(2001)
W. Yang, M. M. Sopper, C. Leystra-Lantz, M. J. Strong, Microtubule-associated tau protein positive neuronal and glial inclusions in ALS. Neurology. ,vol. 61, pp. 1766- 1773 ,(2003) , 10.1212/01.WNL.0000099372.75786.F8
M. J. Strong, W. Yang, W. L. Strong, C. Leystra-Lantz, H. Jaffe, H. C. Pant, Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment Neurology. ,vol. 66, pp. 1770- 1771 ,(2006) , 10.1212/01.WNL.0000218161.15834.DB
Michael J Strong, Sashi Kesavapany, Harish C Pant, The pathobiology of amyotrophic lateral sclerosis: a proteinopathy? Journal of Neuropathology and Experimental Neurology. ,vol. 64, pp. 649- 664 ,(2005) , 10.1097/01.JNEN.0000173889.71434.EA