Evolution of Hepatitis B Virus Polymerase Gene Sequence during Famciclovir Therapy for Chronic Hepatitis B
作者： Béatrice Seignères , Christian Pichoud , Sinafa Si Ahmed , Olivier Hantz , Christian Trépo
DOI: 10.1086/315368
关键词: Nucleoside analogue 、 Hepatitis B virus DNA polymerase 、 Hepatitis B 、 Orthohepadnavirus 、 Lamivudine 、 Hepatitis B virus 、 Famciclovir 、 Biology 、 Hepadnaviridae 、 Virology
摘要: Prolonged administration of nucleoside analogues for chronic hepatitis B may result in the emergence viral polymerase mutants. To gain insight into mechanism involved virus's resistance to famciclovir, amino acid sequences terminal protein and reverse-transcriptase (RT) domains were determined during therapy among 28 patients. The antiviral response was independent genotypes, non-response famciclovir associated with a complex variability RT domain. No mutation YMDD motif observed, whereas an L528M clearly selected by treatment 2 patients, as well 14 novel mutations 7 Clone sequence analysis patients undergoing retreatment andlor lamivudine showed selection preexisting drug-resistant mutant one case indicated that sequential allow rapid resistant strains.
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