Progressive Loss of Corneal and Retinal Nerve Fibers in Patients With Multiple Sclerosis: A 2-Year Follow-up Study.

摘要: Purpose To determine longitudinal alterations in corneal nerve fiber morphology, dendritic cell (DC) density, and retinal layer (RNFL) thickness over 2 years patients with multiple sclerosis (MS). Methods Thirty-one consecutive relapsing-remitting MS (RRMS) underwent assessment of the Kurtzke Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Score (MSSS), confocal microscopy to quantify subbasal morphology DC spectral-domain optical coherence tomography RNFL at baseline after years. Results There was a significant reduction area (CNFA) (P = 0.003), width (CNFW) 0.005), 0.004) an increase EDSS 0.01) The change density (CNFD) correlated (ρ -0.468; P 0.008), MSSS -0.442; 0.01), -0.550; 0.001), 0.472; 0.007). length (CNFL) -0.445; -0.490; 0.005). Furthermore, there decrease CNFL < CNFA 0.02), CNFW 0.04), total branch 0.02) 0.04) worsening (n 15). Conclusions Corneal can be used detect progressive loss that relates progression disability RRMS. Translational Relevance acts as sensitive imaging biomarker for degeneration MS.