Effects of etoposide-induced blood-brain barrier disruption on brain water, intracranial pressure, and cerebral vasomotor tone

摘要: Abstract This study investigated the effects of hypertension and water loading on etoposide-induced, reversible blood-brain barrier disruption in a rat model. Twenty-nine animals were divided into four groups: group 1—intracarotid (i.c.) injection saline followed 1 h by 5 ml i.c. water; 2—i.c. etoposide 3—i.c. i.v. metaraminol to increase systemic blood pressure; 4—i.c. etopside metaraminol. Systemic pressure intracranial monitored continuously. Evans blue staining brain was used as monitor disruption. Animals killed after either aramine or infusion, brains removed inspected for degree After dehydration, calculated each hemisphere. Two-thirds infused with had evidence disruption, whereas none control disrupted. Neither groups 3 showed significant change augmentation pressure, respectively. Group 4 failed demonstrate any despite marked acute (within limits normal autoregulation). A small but statistically noted 2 greatest observed ipsilateral infusion only those most These results indicate that etoposide-induced caused increases without alteration cerebral vasomotor tone except severe The classic untoward consequences vasogenic edema not encountered present