Combination chemotherapy of nafamostat mesylate with gemcitabine for gallbladder cancer targeting nuclear factor-κB activation.

作者: Ryota Iwase , Koichiro Haruki , Yuki Fujiwara , Kenei Furukawa , Hiroaki Shiba

DOI: 10.1016/J.JSS.2013.06.003

关键词: Subcutaneous injectionMedicineGemcitabineCancer researchApoptosisPancreatic cancerInternal medicineOncologyCombination chemotherapyGallbladder cancerCell cultureNF-κB

摘要: … To evaluate the inhibitory effect of nafamostat mesylate on NF-κB signaling resulting from suppression of IκBα phosphorylation, phosphorylated IκBα and IκBα levels of NOZ cells were …

参考文章(43)
Cun-Yu Wang, James C. Cusack, Rong Liu, Albert S. Baldwin, Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB Nature Medicine. ,vol. 5, pp. 412- 417 ,(1999) , 10.1038/7410
D. J. Van Antwerp, S. J. Martin, T. Kafri, D. R. Green, I. M. Verma, Suppression of TNF-α-Induced Apoptosis by NF-κB Science. ,vol. 274, pp. 787- 789 ,(1996) , 10.1126/SCIENCE.274.5288.787
Hirokazu Noshiro, Masazumi Tsuneyoshi, Takeharu Yamanaka, Kentaro Hashizume, Masao Tanaka, Kenjiro Nakamura, Takashi Yao, Akihiko Uchiyama, Takashi Morisaki, Mitsuo Katano, Nobuhiko Sasaki, Nuclear Factor-κB p65 (RelA) Transcription Factor Is Constitutively Activated in Human Gastric Carcinoma Tissue Clinical Cancer Research. ,vol. 7, pp. 4136- 4142 ,(2001)
A. A. Beg, D. Baltimore, An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death Science. ,vol. 274, pp. 782- 784 ,(1996) , 10.1126/SCIENCE.274.5288.782
Wujun Wu, Cheng'en Pan, Haibo Yu, Huilin Gong, Youli Wang, Heparanase expression in gallbladder carcinoma and its correlation to prognosis. Journal of Gastroenterology and Hepatology. ,vol. 23, pp. 491- 497 ,(2008) , 10.1111/J.1440-1746.2007.04945.X
Paolo Onori, Sharon DeMorrow, Eugenio Gaudio, Antonio Franchitto, Romina Mancinelli, Julie Venter, Shelley Kopriva, Yoshiyuki Ueno, Domenico Alvaro, Jennifer Savage, Gianfranco Alpini, Heather Francis, Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-κB and induction of apoptosis International Journal of Cancer. ,vol. 125, pp. 565- 576 ,(2009) , 10.1002/IJC.24271
Wunchana Seubwai, Kulthida Vaeteewoottacharn, Masateru Hiyoshi, Shinya Suzu, Anucha Puapairoj, Chairisi Wongkham, Seiji Okada, Sopit Wongkham, Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF‐κB Cancer Science. ,vol. 101, pp. 1590- 1595 ,(2010) , 10.1111/J.1349-7006.2010.01572.X
Mi-Jung Kim, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Seock-Ah Im, Tae-You Kim, Dae Seog Heo, Yung-Jue Bang, None, Gemcitabine-based versus fluoropyrimidine-based chemotherapy with or without platinum in unresectable biliary tract cancer: a retrospective study BMC Cancer. ,vol. 8, pp. 374- 374 ,(2008) , 10.1186/1471-2407-8-374
Koichiro Haruki, Hiroaki Shiba, Yuki Fujiwara, Kenei Furukawa, Ryota Iwase, Tadashi Uwagawa, Takeyuki Misawa, Toya Ohashi, Katsuhiko Yanaga, Inhibition of Nuclear Factor-κB Enhances the Antitumor Effect of Paclitaxel Against Gastric Cancer with Peritoneal Dissemination in Mice Digestive Diseases and Sciences. ,vol. 58, pp. 123- 131 ,(2013) , 10.1007/S10620-012-2311-4
Tao Lu, George R. Stark, Cytokine Overexpression and Constitutive NFκB in Cancer Cell Cycle. ,vol. 3, pp. 1114- 1117 ,(2004) , 10.4161/CC.3.9.1130