Theaflavin-3,3'-Digallate Suppresses Human Ovarian Carcinoma OVCAR-3 Cells by Regulating the Checkpoint Kinase 2 and p27 kip1 Pathways.
作者： Ying Gao , Junfeng Yin , Youying Tu , Yi Chen
DOI: 10.3390/MOLECULES24040673
关键词: Signal transduction 、 Checkpoint Kinase 2 、 Intrinsic apoptosis 、 G1 phase 、 Cancer research 、 Ovarian carcinoma 、 Chemistry 、 Apoptosis 、 Cell cycle checkpoint 、 Ovarian cancer
摘要: Theaflavin-3,3'-digallate (TF3) is a unique polyphenol in black tea. Epidemiological studies have proved that tea consumption decreases the incidence rate of ovarian cancer. Our former research demonstrated TF3 inhibited human cancer cells. Nevertheless, roles checkpoint kinase 2 (Chk2) and p27 kip1 (p27) TF3-mediated inhibition cells not yet been investigated. In current study, enhanced phosphorylation Chk2 to modulate ratio pro/anti-apoptotic Bcl-2 family proteins initiate intrinsic apoptosis p53-independent manner increased expression death receptors activate extrinsic OVCAR-3 carcinoma addition, up-regulated induce G0/G1 cell cycle arrest study indicated were vital anticancer targets provided more evidence might be potent agent applied as adjuvant treatment for
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