Measurement of Paraoxonase (PON1) Status as a Potential Biomarker of Susceptibility to Organophosphate Toxicity
作者： Lucio G. Costa , Toby B. Cole , Annabella Vitalone , Clement E. Furlong
DOI: 10.1016/J.CCCN.2004.09.019
关键词: Genetic predisposition 、 PON1 、 Acute toxicity 、 Cholinesterase 、 Paraoxonase 、 Acetylcholinesterase 、 Toxicity 、 Poison control 、 Pharmacology 、 Medicine
摘要: Organophosphorus (OP) compounds are still among the most widely used insecticides, and their main mechanism of acute toxicity is associated with inhibition acetylcholinesterase. Measurements urine metabolites blood cholinesterase activity established biomarkers exposure to OPs early biological effects. In recent years, increasing attention has been given susceptibility OP toxicity. Here we discuss polymorphisms paraoxonase (PON1), a liver serum enzyme that hydrolyzes number compounds, its role in modulating OPs. We stress importance determining PON1 status, which encompasses PON1192Q/R polymorphism (that affects catalytic ability toward different substrates) levels (which modulated part by C-108T polymorphism) over straight genotyping. Epidemiological studies on OP-exposed workers include assessment status validate human populations as determinant OPs, indicated animal studies, needed. Documentation health effects would be relevant increase predictive value test.
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