Complement activation in hidradenitis suppurativa: a new pathway of pathogenesis?

作者: T. Kanni , O. Zenker , M. Habel , N. Riedemann , E.J. Giamarellos-Bourboulis

DOI: 10.1111/BJD.16428

关键词: PathogenesisPeripheral blood mononuclear cellComplement factor IComplement membrane attack complexComplement systemAnaphylatoxinHidradenitis suppurativaImmunologyNecrosisMedicine

摘要: … C5b‐9 concentration was determined using the BD OptEIA™ Human C5b‐9 ELISA Set (BD … of severity had greater concentrations of C5a and C5b‐9 than healthy controls; however, …

参考文章(20)
Theodora Kanni, Vassiliki Tzanetakou, Athina Savva, Brigit Kersten, Aikaterini Pistiki, Frank L. van de Veerdonk, Mihai G. Netea, Jos W. van der Meer, Evangelos J. Giamarellos-Bourboulis, Compartmentalized Cytokine Responses in Hidradenitis Suppurativa PLOS ONE. ,vol. 10, pp. e0130522- ,(2015) , 10.1371/JOURNAL.PONE.0130522
H.H. van der Zee, L. de Ruiter, D.G. van den Broecke, W.A. Dik, J.D. Laman, E.P. Prens, Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β. British Journal of Dermatology. ,vol. 164, pp. 1292- 1298 ,(2011) , 10.1111/J.1365-2133.2011.10254.X
H.H. van der Zee, L. de Ruiter, J. Boer, D.G. van den Broecke, J.C. den Hollander, J.D. Laman, E.P. Prens, Alterations in leucocyte subsets and histomorphology in normal‐appearing perilesional skin and early and chronic hidradenitis suppurativa lesions British Journal of Dermatology. ,vol. 166, pp. 98- 106 ,(2012) , 10.1111/J.1365-2133.2011.10643.X
E Mozeika, M Pilmane, B Nürnberg, G Jemec, Tumour necrosis factor-alpha and matrix metalloproteinase-2 are expressed strongly in hidradenitis suppurativa. Acta Dermato-venereologica. ,vol. 93, pp. 301- 304 ,(2013) , 10.2340/00015555-1492
J.M. Von Der Werth, G.B.E. Jemec, Morbidity in patients with hidradenitis suppurativa British Journal of Dermatology. ,vol. 144, pp. 809- 813 ,(2001) , 10.1046/J.1365-2133.2001.04137.X
Angelo V. Marzano, Isabella Ceccherini, Marco Gattorno, Daniele Fanoni, Francesco Caroli, Marta Rusmini, Alice Grossi, Clara De Simone, Orietta M. Borghi, Pier Luigi Meroni, Carlo Crosti, Massimo Cugno, Association of Pyoderma Gangrenosum, Acne, and Suppurative Hidradenitis (PASH) Shares Genetic and Cytokine Profiles With Other Autoinflammatory Diseases Medicine. ,vol. 93, pp. 187- ,(2014) , 10.1097/MD.0000000000000187
J. Jason Hoth, Jonathan D. Wells, Sarah E. Jones, Barbara K. Yoza, Charles E. McCall, Complement mediates a primed inflammatory response after traumatic lung injury. Journal of Trauma-injury Infection and Critical Care. ,vol. 76, pp. 601- 609 ,(2014) , 10.1097/TA.0000000000000129
K. Sartorius, J. Lapins, L. Emtestam, G.B.E. Jemec, Suggestions for uniform outcome variables when reporting treatment effects in hidradenitis suppurativa British Journal of Dermatology. ,vol. 149, pp. 211- 213 ,(2003) , 10.1046/J.1365-2133.2003.05390.X
Jean E. Revuz, Florence Canoui-Poitrine, Pierre Wolkenstein, Cedric Viallette, Germaine Gabison, Florence Pouget, Florence Poli, Ousmane Faye, Jean Claude Roujeau, Genevieve Bonnelye, Jean Jacques Grob, Sylvie Bastuji-Garin, Prevalence and factors associated with hidradenitis suppurativa: Results from two case-control studies Journal of The American Academy of Dermatology. ,vol. 59, pp. 596- 601 ,(2008) , 10.1016/J.JAAD.2008.06.020
Ruobing Wang, Bao Lu, Craig Gerard, Norma P. Gerard, Disruption of the Complement Anaphylatoxin Receptor C5L2 Exacerbates Inflammation in Allergic Contact Dermatitis The Journal of Immunology. ,vol. 191, pp. 4001- 4009 ,(2013) , 10.4049/JIMMUNOL.1301626