Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice

摘要: UV light suppresses experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for the decreased incidence MS equatorial regions. To test this concept further, we applied commercially available sunblock preparations to before exposing them radiation. Surprisingly, some blocked EAE without Furthermore, various had variable ability suppress EAE. By examining components most effective agents, identified homosalate octisalate as suppressing Thus, salates useful stopping progression provide new insight into mechanisms controlling disease.