Changes in T2*-weighted images during hyperoxia differentiate tumors from normal tissue.
作者： Vadim Y U. Kuperman , Jonathan N. River , Martha Z. Lewis , Leslie M. Lubich , Gregory S. Karczmar
关键词: Hyperoxia 、 Oxygene 、 Pathology 、 Magnetic resonance imaging 、 Blood pressure 、 T2 weighted 、 Normal tissue 、 Intensity (physics) 、 Transplantation 、 Chemistry
摘要: Experiments were performed to determine whether changes in T 2 *-weighted MR images during and after hyperoxia differentiate tumors from normal tissue. Mammary adenocarcinomas implanted the right hind limbs of rats studied. Gradient echo obtained at Tesla with an evolution time 20 ms a recycle 1 s. Breathing gas was either air or 100% O . Significant increases image intensity observed tumor centers rims while much smaller detected surrounding muscle. The relaxation rate (1/T *) decreased by average 2.5 ± 1.0 s −1 , muscle change increase 0.6 2.1 largest decreases non-necrotic regions relatively low density blood vessels. Immediately following significant
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