Advances in the pathophysiology and treatment of heart failure with preserved ejection fraction

作者: Sara Tannenbaum , Gabriel T. Sayer

DOI: 10.1097/HCO.0000000000000163

关键词: CardiologyHeart failure with preserved ejection fractionMedicinePathophysiologyInternal medicineCardiology and Cardiovascular Medicine

摘要: Purpose of reviewWith the failure multiple trials to identify a successful therapy for heart with preserved ejection fraction (HFpEF), attention has shifted defining specific phenotypes within HFpEF spectrum in an effort develop targeted approach treatment. Here we summariz

参考文章(53)
Dalane W. Kitzman, Peter H. Brubaker, David M. Herrington, Timothy M. Morgan, Kathryn P. Stewart, W. Gregory Hundley, Abdelhamed Abdelhamed, Mark J. Haykowsky, Effect of Endurance Exercise Training on Endothelial function and Arterial Stiffness in Older Patients with Heart Failure and Preserved Ejection Fraction: A Randomized, Controlled, Single-Blind Trial Journal of the American College of Cardiology. ,vol. 62, pp. 584- 592 ,(2013) , 10.1016/J.JACC.2013.04.033
Dalane W. Kitzman, Bharathi Upadhya, Heart Failure With Preserved Ejection Fraction Journal of the American College of Cardiology. ,vol. 63, pp. 457- 459 ,(2014) , 10.1016/J.JACC.2013.10.007
Pardeep S. Jhund, Brian Claggett, Milton Packer, Michael R Zile, Adriaan A. Voors, Burkert Pieske, Martin Lefkowitz, Victor Shi, Toni Bransford, John J. V. McMurray, Scott D Solomon, Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: An analysis of the PARAMOUNT trial European Journal of Heart Failure. ,vol. 16, pp. 671- 677 ,(2014) , 10.1002/EJHF.76
Michael Böhm, Ana-Cristina Perez, Pardeep S. Jhund, Jan C. Reil, Michel Komajda, Michael R. Zile, Robert S McKelvie, Inder S Anand, Barry M. Massie, Peter E. Carson, John J. V. McMurray, , Relationship between heart rate and mortality and morbidity in the irbesartan patients with heart failure and preserved systolic function trial (I-Preserve). European Journal of Heart Failure. ,vol. 16, pp. 778- 787 ,(2014) , 10.1002/EJHF.85
Lars Søndergaard, Vivek Reddy, David Kaye, Filip Malek, Antony Walton, Martin Mates, Olaf Franzen, Petr Neuzil, Nikolaj Ihlemann, Finn Gustafsson, Transcatheter treatment of heart failure with preserved or mildly reduced ejection fraction using a novel interatrial implant to lower left atrial pressure European Journal of Heart Failure. ,vol. 16, pp. 796- 801 ,(2014) , 10.1002/EJHF.111
Wojciech Kosmala, David J. Holland, Aleksandra Rojek, Leah Wright, Monika Przewlocka-Kosmala, Thomas H. Marwick, Effect of If-channel inhibition on hemodynamic status and exercise tolerance in heart failure with preserved ejection fraction: a randomized trial. Journal of the American College of Cardiology. ,vol. 62, pp. 1330- 1338 ,(2013) , 10.1016/J.JACC.2013.06.043
Brian R. Lindman, Victor G. Dávila-Román, Douglas L. Mann, Steven McNulty, Marc J. Semigran, Gregory D. Lewis, Lisa de las Fuentes, Susan M. Joseph, Justin Vader, Adrian F. Hernandez, Margaret M. Redfield, Cardiovascular Phenotype in HFpEF Patients With or Without Diabetes: A RELAX Trial Ancillary Study Journal of the American College of Cardiology. ,vol. 64, pp. 541- 549 ,(2014) , 10.1016/J.JACC.2014.05.030
Mauro Gori, Carolyn S. P. Lam, Deepak K. Gupta, Angela B. S. Santos, Susan Cheng, Amil M. Shah, Brian Claggett, Michael R. Zile, Elisabeth Kraigher-Krainer, Burkert Pieske, Adriaan A. Voors, Milton Packer, Toni Bransford, Martin Lefkowitz, John J. V. McMurray, Scott D. Solomon, , Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction European Journal of Heart Failure. ,vol. 16, pp. 535- 542 ,(2014) , 10.1002/EJHF.67
Vojtech Melenovsky, Seok-Jae Hwang, Grace Lin, Margaret M. Redfield, Barry A. Borlaug, Right heart dysfunction in heart failure with preserved ejection fraction European Heart Journal. ,vol. 35, pp. 3452- 3462 ,(2014) , 10.1093/EURHEARTJ/EHU193