Amoebicidal Activity of Essential Oil of Dysphania ambrosioides (L.) Mosyakin & Clemants in an Amoebic Liver Abscess Hamster Model.
作者： Manuel Enrique Ávila-Blanco , Martín Gerardo Rodríguez , José Luis Moreno Duque , Martin Muñoz-Ortega , Javier Ventura-Juárez
DOI: 10.1155/2014/930208
关键词: Oral administration 、 Ascaridole 、 Traditional medicine 、 Dysphania ambrosioides 、 Amoebic liver abscess 、 Entamoeba histolytica 、 Pathology 、 Essential oil 、 Metronidazole 、 Hamster 、 Medicine
摘要: Amebiasis is a parasitic disease that extends worldwide and public health problem in developing countries. Metronidazole the drug recommended treatment of amebiasis, but its contralateral effects lack continuity induce low efficiency, coupled with appearance resistant amoebic strains. Therefore, search new compounds amoebicidal activity urgent important. In this study, we evaluated vitro vivo antiamoebic essential oil Dysphania ambrosioides (L.) Mosyakin & Clemants. It exhibited an IC50 = 0.7 mg/mL against trophozoites. The oral administration (8 mg/kg 80 mg/kg) to hamster infected Entamoeba histolytica reverted infection. Ascaridole was identified as main component D. ambrosioides. identification gives support traditional use. Further studies will be carried out understand mechanism involved.
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