Management of acute hepatitis B and reactivation of hepatitis B

摘要: The natural course of hepatitis B virus infection and the resulting hepatic injury is determined by degree replication intensity host immune response. Upon exposure to (HBV), individuals with a vigorous broad response develop acute self-limited infection, which may result in hepatitis. However, stringent testing for HBV universal precautions, rather rare. Reactivation most often presents as (AVH-B) clinically, it difficult differentiate AVH-B from reactivation chronic (CHB) requires high index suspicion. In presence DNA (>2 × 10(4) IU/ml) underlying liver disease should be investigated biopsy, endoscopy and/or imaging. failure depends on severity insult stage disease. Mutations genome, immunosuppressive therapy viral or drug induced are common causes reactivation. As patients resolve spontaneously, antiviral not indicated them. use potent oral nucleoside(tide) analogue necessary soon possible CHB Liver transplantation considered who secondary severe exacerbation. If this feasible, supportive addition granulocyte colony stimulating factor (GCSF) could beneficial.