Reactivity of phospha-Wittig reagents towards NHCs and NHOs.
作者： Malte Fischer , Jan-Erik Siewert , Christian Hering-Junghans , Priyanka Gupta , Wolgang Baumann
DOI: 10.1039/D1DT00071C
关键词: Wittig reaction 、 Reactivity (chemistry) 、 Medicinal chemistry 、 Reagent 、 Chemistry
摘要: Phospha-Wittig reagents, RPPMe3 (R = Mes* 2,4,6-tBu3-C6H2; MesTer 2,6-(2,4,6-Me3C6H2)-C6H3; DipTer 2,6-(2,6-iPr2C6H3)-C6H3), can be considered as phosphine-stabilized phosphinidenes. In this study we show that PMe3 displaced by NHCs or NHOs. Interestingly, phosphinidene-like reactivity results in a subsequent C(sp2)-H activation of the exocyclic CH2 group This concept was further extended to allyl-apended NHOs, which resulted phosphine-substituted allyl species.
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