Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli.
作者： Ki Baek Lee , Dong Hyun Nam , Jacob A. M. Nuhn , Juan Wang , Ian C. Schneider
DOI: 10.1186/S12934-017-0686-9
关键词: Context (language use) 、 Inclusion bodies 、 Escherichia coli 、 Biochemistry 、 Biology 、 ADAMTS 、 Tissue inhibitor of metalloproteinase 、 Protein disulfide-isomerase 、 Periplasmic space 、 Matrix metalloproteinase
摘要: As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal role in extracellular matrix remodeling, which is involved in a wide variety of physiological processes. Since abnormal metalloproteinase activities are related to numerous diseases such as arthritis, cancer, atherosclerosis, and neurological disorders, TIMPs and their engineered mutants hold therapeutic potential and thus have been extensively studied. Traditional productions of …
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