The Impact of Tumour Characteristics on Hereditary Breast Cancer Screening

摘要: textabstractIn the Western world breast cancer is a fairly common disease in women, nearly one in ten diagnosed with during her life. Worldwide 1.200.000 women are diagnosed with annually, Netherlands about 12.000, 25% of them before age 50 years 1. incidence doubled between 1975 and 2000, steepest increase developing countries. Survival has clearly improved last decade, mainly as result earlier detection by women’s awareness mammography screening, and also increased use adjuvant hormonal chemotherapy 2,3. The diagnosis still frightening as approximately 3.500 die annually metastases the Netherlands, but an increasing number survives after disease. The main risk factors for associated with; age, family history previous cancer. Only small fraction, 20%, all breast deaths western worldwide estimated to be caused by preventable behavioural risk-factors like physical inactivity, obesity, alcohol consumption and replacement therapy (HRT) 4. These influence hormonal balance, leading instance early menarche late menopause, that are known increase risk. Like postmenopausal replacement therapy, nulliparity, harmful effect seems cumulative exposure ovarian hormones/ ovulatory cycles. While also preventive prolonged breast-feeding may reduced cycles, protective first full-term pregnancy at relatively young age terminal differentiation the breast epithelium. cycles and the decrease explained their on the cell divisions epithelial cells accumulation molecular and DNA damage.