The dual nature of hypothalamic-pituitary-adrenal axis regulation in dyads of very preterm infants and their mothers

摘要: Abstract The co-regulation of the hypothalamic-pituitary-adrenal (HPA) axis in mother-infant dyads is thought to be key for infant and child development. Nonetheless, previous literature presents some inconsistencies that might at least partially due presence risk conditions use different statistical approaches measure HPA co-regulation. Very preterm (VPT) birth represents one these as early foundation interaction disrupted. Both VPT infants their mothers present evidence altered regulation. comparison compared full-term (FT) ones has not been previously investigated. In this study, 3-month-old (corrected age) FT counterparts with took part a well-validated stress-inducing laboratory task (i.e., double Face-to-Face Still-Face, FFSF paradigm). Salivary cortisol samples were obtained before (Baseline) after (Early reactivity, Late reactivity Recovery) procedure. Dyadic was assessed each sample time-point in-moment coupling) well across in-time synchrony). Significant coupling emerged Baseline, Recovery infants’ only. An overlying pattern salivary trajectories between group, whereas more complex reciprocal complementary found dyads. Although both groups gave co-regulation, appear less able adapt reciprocally dynamically stressful conditions. These findings suggest multiple account dyadic should used order depict biological rhythms coordination