Bioinformatic analysis of post-transcriptional regulation by uORF in human and mouse
作者： Motomu Matsui , Nozomu Yachie , Yuki Okada , Rintaro Saito , Masaru Tomita
DOI: 10.1016/J.FEBSLET.2007.07.057
关键词: Gene expression 、 Transcription (biology) 、 Genetics 、 RNA 、 Messenger RNA 、 Five prime untranslated region 、 Biology 、 Nonsense-mediated decay 、 Upstream open reading frame 、 Post-transcriptional regulation 、 Biophysics 、 Cell biology 、 Biochemistry 、 Molecular biology 、 Structural biology
摘要: RNA decay is thought to exert an important influence on gene expression by maintaining a steady-state level of transcripts and/or eliminating aberrant transcripts. However, the sequence elements which control such processes have not been determined. Upstream open reading frames (uORFs) in several genes are reported translational initiation stalling ribosomes and thereby promote decay. We therefore performed bioinformatic analysis tissue-wide profiles mRNA half-life containing uORFs humans mice assess relationship between presence The levels uORF were markedly lower than those uORF. Moreover, uORF-containing was also shorter. These results suggest that down-regulate via mechanisms.
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