Failure of Pancreatic Cancer Chemotherapy: Consequences of Drug Resistance Mechanisms

摘要: Pancreatic cancer is one of the most lethal forms and it estimated that there will be about 44,000 new cases in US year 2011. With 37,600 deaths 2011, pancreatic fourth leading cause related (American Cancer Society, 2011). In spite numerous efforts, 5-year survival rate for has not improved much last few decades. The suggested reasons low among patients include late disease diagnosis, highly invasive metastatic nature, lack effective therapies, acquisition resistant characteristics Society 2007; Moore, et al., 2003; NIH 2007). Only two drugs – gemcitabine (GEM) 5fluorouracil (5FU) have been shown to improve consistently. 5FU was first drug approved as adjuvant therapy (Kalser Ellenberg, 1985; Moertel, 1981). Since then, GEM used line chemotherapeutic cancer. However, treatment does always provide extended benefits. A study found post-operative patients, increased by merely 6 months (Shore, 2003). also widely an neoadjuvant agent treat cancers (Ahlgren, 1996; Blaszkowsky, 1998; Snady, 2000).