Selective decontamination with nystatin for control of a Candida outbreak in a neonatal intensive care unit
作者： V. Damjanovic , C.M. Connolly , H.K.F. van Saene , R.W.I. Cooke , J.E. Corkill
DOI: 10.1016/0195-6701(93)90057-7
关键词: Throat 、 Medicine 、 Nystatin 、 Intensive care unit 、 Internal medicine 、 Candida parapsilosis 、 Neonatal intensive care unit 、 Fungemia 、 Outbreak 、 Surgery 、 Carriage 、 Microbiology (medical) 、 Infectious Diseases 、 General Medicine
摘要: Selective decontamination of the digestive tract (SDD) with oral nystatin was evaluated as a measure to control an outbreak Candida infection in neonatal intensive care unit (NICU). Seventy-six out 106 neonates who carried spp. received main study manoeuvre (the application throat and stomach) during 12-month open trial. One third weighed < 1500 g whilst about half were being ventilated. The mean stay 33.2 d (SD +/- 46.9). Two cases candidaemia within fortnight associated yeast carriage rate NICU 50%; more than 80% isolates parapsilosis. During implementation period there four new fungaemia caused by C. Once dropped below 5% (P 0.001), no systemic strain recognized following 8 months. It took 3.5 months outbreak. observation that all other clinical diagnostic samples free from suggests translocation or gut into circulation occurred. SDD effective reducing index (mean 1.93, before SDD; 0.45, after P 0.001). A significant reduction carriage, both rates indices, is thought have contributed this candida
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