Treatment of neoplastic meningitis by targeted radiation using 131I-radiolabelled monoclonal antibodies

作者: Hugh B. Coakham , John T. Kemshead

DOI: 10.1023/A:1005996606073

关键词: Central nervous systemNeoplastic meningitisAnticorps monoclonalProgressive diseaseNeurologyMonoclonal antibodyMeningeal carcinomatosisImmunotherapyPathologyMedicine

摘要: Between 1984 and 1993, monoclonal antibodies (MAbs) radiolabelled with 131I were administered into the CSF of 52 patients neoplastic meningitis (meningosis) progressive disease despite active conventional therapy. Selection MAbs was based on immunoreactivity patients' tumour lack binding to normal central nervous system (CNS) tissue.

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