作者: Hugh B. Coakham , John T. Kemshead
关键词: Central nervous system 、 Neoplastic meningitis 、 Anticorps monoclonal 、 Progressive disease 、 Neurology 、 Monoclonal antibody 、 Meningeal carcinomatosis 、 Immunotherapy 、 Pathology 、 Medicine
摘要: Between 1984 and 1993, monoclonal antibodies (MAbs) radiolabelled with 131I were administered into the CSF of 52 patients neoplastic meningitis (meningosis) progressive disease despite active conventional therapy. Selection MAbs was based on immunoreactivity patients' tumour lack binding to normal central nervous system (CNS) tissue.