Natural Behavior Polymorphism Due to a cGMP-Dependent Protein Kinase of Drosophila
作者： KA Osborne , A Robichon , E Burgess , S Butland , RA Shaw
DOI: 10.1126/SCIENCE.277.5327.834
关键词: Regulator gene 、 Transgene 、 Protein kinase A 、 cGMP-dependent protein kinase 、 Gene 、 Biology 、 Complementary DNA 、 Genetics 、 Drosophilidae 、 Drosophila melanogaster 、 Multidisciplinary
摘要: Naturally occuring polymorphisms in behavior are difficult to map genetically and thus refractory molecular characterization. An exception is the foraging gene (for), a that has two naturally occurring variants Drosophila melanogaster food-search behavior: rover sitter. Molecular mapping placed for mutations dg2 gene, which encodes cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, transgenic sitters expressing complementary DNA from showed transformation of rover. Thus, levels affected behavior, natural variation accounted behavioral polymorphism.
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