The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours.
作者： Felisbina L. Queiroga , Isabel Pires , Luís Lobo , Carlos S. Lopes
DOI: 10.1016/J.RVSC.2009.10.009
关键词: Animal mortality 、 Histology 、 Internal medicine 、 Pathology 、 Immunohistochemistry 、 Metastasis 、 Adjuvant therapy 、 Survival rate 、 Oncology 、 Lymph 、 Medicine 、 Carcinoma
摘要: Immunohistochemical detection of Cyclooxygenase (Cox)-1 and -2 enzymes in canine mammary tumours (CMT) has recently been described. However, the prognostic value their expression needs to be established. The aim this study was investigate Cox (-1 -2) malignant CMT by evaluating its correlation with clinicopathological parameters (tumour size, histological type, necrosis, lymph node metastasis) Disease Free Survival (DFS) Overall (OS). Twenty seven female dogs were included. Cox-2 associated metastasis at surgery time, development distant during follow-up (p = 0.038), DFS 0.03) OS 0.04). Multivariate survival analysis showed that did not retain significance as an independent factor. For Cox-1 expression, no statistically significant association observed. Present suggests usefulness testing specific inhibitors part adjuvant therapy neoplasias.
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McQuay, Moore, Eccleston, Morley, Williams, Systematic review of outpatient services for chronic pain control. Health Technology Assessment. ,vol. 1, pp. 1- 135 ,(1997) , 10.3310/HTA1060
NINA STRATMANN, KLAUS FAILING, ANDREAS RICHTER, AXEL WEHREND, Mammary tumor recurrence in bitches after regional mastectomy. Veterinary Surgery. ,vol. 37, pp. 82- 86 ,(2008) , 10.1111/J.1532-950X.2007.00351.X
MD Perez Alenza, L Pena, N del Castillo, AI Nieto, None, Factors influencing the incidence and prognosis of canine mammary tumours Journal of Small Animal Practice. ,vol. 41, pp. 287- 291 ,(2000) , 10.1111/J.1748-5827.2000.TB03203.X
F. Millanta, S. Citi, D. Della Santa, M. Porciani, A. Poli, COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers. Breast Cancer Research and Treatment. ,vol. 98, pp. 115- 120 ,(2006) , 10.1007/S10549-005-9138-Z
Norio Yoshimura, Hajime Sano, Masahiko Okamoto, Kiyokazu Akioka, Hidetaka Ushigome, Yayoi Kadotani, Rikio Yoshimura, Shuji Nobori, Atsushi Higuchi, Yoshihiro Ohmori, Kenji Nakamura, Expression of Cyclooxygenase-1 and -2 in Human Breast Cancer Surgery Today. ,vol. 33, pp. 805- 811 ,(2003) , 10.1007/S00595-003-2606-3
Y Chen, P Jobanputra, P Barton, S Bryan, A Fry-Smith, G Harris, R Taylor, Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation Health Technology Assessment. ,vol. 12, pp. 1- ,(2008) , 10.3310/HTA12110
L. Marconato, R. M. Lorenzo, F. Abramo, A. Ratto, E. Zini, Adjuvant gemcitabine after surgical removal of aggressive malignant mammary tumours in dogs Veterinary and Comparative Oncology. ,vol. 6, pp. 90- 101 ,(2008) , 10.1111/J.1476-5829.2007.00143.X
Joseph A. Impellizeri, D. Glen Esplin, Expression of cyclooxygenase-2 in canine nasal carcinomas Veterinary Journal. ,vol. 176, pp. 408- 410 ,(2008) , 10.1016/J.TVJL.2007.03.022
Xiao-Hua Zhang, Du-Ping Huang, Gui-Long Guo, Guo-Rong Chen, Hu-Xiang Zhang, Li Wan, Sheng-Ying Chen, Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. BMC Cancer. ,vol. 8, pp. 4- 4 ,(2008) , 10.1186/1471-2407-8-4
Gurpreet Singh-Ranger, Mohamed Salhab, Kefah Mokbel, The role of cyclooxygenase-2 in breast cancer: review. Breast Cancer Research and Treatment. ,vol. 109, pp. 189- 198 ,(2008) , 10.1007/S10549-007-9641-5