Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms

作者: Alessio Nocentini , Alessandro Bonardi , Paola Gratteri , Bruno Cerra , Antimo Gioiello

DOI: 10.1080/14756366.2018.1512597

关键词: Carbonic anhydrase activityHormoneGastrointestinal tractBile acidBiochemistryCarbonic anhydraseChemistryCancer

摘要: Bile acids have been shown to inhibit human (h) carbonic anhydrases (CA, EC 4.2.1.1) along the gastrointestinal tract, including hCA II. The elucidation of hormonal inhibition mechanism ...

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